Phenotypes Associated with This Genotype

Genotype
MGI:3617809

• Allelic Composition: Exoc6^hbd/Exoc6^hbd
• Genetic Background: B6.Cg-Exoc6^hbd/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

microcytic anemia ( J:42436 , J:105712 )

abnormal erythrocyte morphology ( J:105712 )

abnormal erythropoiesis ( J:42436 )

• wild-type recipients of bone marrow transplants from homozygotes develop microcytic anemia like homozygotes, however repopulation with mutant marrow is slower than with wild-type marrow and mutant marrow makes no significant contribution to repopulation in mixed repopulation experiments

decreased hematocrit ( J:42436 , J:105712 )

decreased hemoglobin content ( J:42436 , J:105712 )

decreased mean corpuscular hemoglobin concentration ( J:42436 )

decreased mean corpuscular volume ( J:42436 , J:105712 )

increased erythrocyte protoporphyrin level ( J:42436 )

• elevation in zinc protoporphyrin levels

microcytosis ( J:42436 )

homeostasis/metabolism

increased erythrocyte protoporphyrin level ( J:42436 )

• elevation in zinc protoporphyrin levels

abnormal iron homeostasis ( J:105712 )

• elevation in zinc protoporphyrin levels, suggesting ineffective utilization of iron