Phenotypes Associated with This Genotype

Genotype
MGI:3618377

• Allelic Composition: Mapk8ip1^tm1Wae/Mapk8ip1^tm1Wae
• Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:70600 )

• homozygotes die prior to blastocyst implantation, with less than 1% of mutant embryos surviving to E3.5

• early embryonic lethality is attributed to poor survival of fertilized mutant oocytes

cellular

abnormal cell death ( J:70600 )

• in culture, no homozygous mutant embryos are identified as early as two-cell stage, indicating accelerated cell death during the first cell cycles