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Phenotypes Associated with This Genotype
Genotype
MGI:3619056
Allelic
Composition		 Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)3Ell/0
Genetic
Background		 NOD.Cg-Ins2tm1Jja Tg(Ins2*Y16A)3Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2tm1Jja mutation (4 available); any Ins2 mutation (93 available)
Tg(Ins2*Y16A)3Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:98583 )
• transgenic female mice lacking the Ins2 gene do not show increased resistance to diabetes development compared to nontransgenic NOD animals lacking the gene
increased anti-insulin autoantibody level ( J:98583 )
• female mice having the insulin 1 gene but lacking the insulin 2 gene produce insulin autoantibodies

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory