Phenotypes Associated with This Genotype

Genotype
MGI:3619718

• Allelic Composition: Aifm2^tm1Hbsh/Aifm2^tm1Hbsh
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell proliferation ( J:105660 )

• homozygous MEFs are less sensitive to genotoxin (doxorubicin, 5-fluorouracil, or etoposide) induced growth inhibition

• however, genotoxin induced apoptosis is similar to wild-type

neoplasm

neoplasm ( J:105660 )

N • no increase in spontaneous tumors or change in MCA-induced sarcoma incidence are seen and homozygous mice are viable and fertile with no gross abnormalities