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Phenotypes Associated with This Genotype
Genotype
MGI:3620042
Allelic
Composition		 Bub1btm1.1Jvd/Bub1b+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1btm1.1Jvd mutation (0 available); any Bub1b mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:194926 )
• reduced median (90 vs. 102 weeks) without a reduction in maximum lifespan

cellular
abnormal cell cycle checkpoint function ( J:105717 )
• after nocodazole treatment the time for 50% of cells to exit prometaphase arrest is reduced to 3.8 hours compared to 7.2 hours for wild-type MEFs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory