Phenotypes Associated with This Genotype

Genotype
MGI:3620644

• Allelic Composition: Hey2^tm1Gess/Hey2^tm1Gess
• Genetic Background: B6.129P2-Hey2^tm1Gess

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ventricular and atrial septal defects in Hey2^tm1Gess/Hey2^tm1Gess mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:93980 )

• Background Sensitivity: 80-90% die within 10 days after birth, unlike on a CD-1 background in which lethality rates are much lower

cardiovascular system

abnormal cardiovascular system morphology ( J:93980 )

• Background Sensitivity: exhibit more severe cardiac defects on the C57BL/6 background than on a CD-1 background

tricuspid valve atresia ( J:93980 )

• 8 of 15 at E13.5-E16.5 lack an open connection between the right atrium and ventricle, although the leaflets of the tricuspid valve are formed

tricuspid valve stenosis ( J:93980 )

patent cardiac foramen ovale ( J:93980 )

• show persistent foramen ovale

perimembraneous ventricular septal defect ( J:93980 )

• Background Sensitivity: ventricular septal defects are much more severe than on a CD-1 background

• high incidence of ventricular septal defects that are consistently located in the upper membranous part of the ventricular septum, just below the atrioventricular junction

abnormal heart shape ( J:93980 )

• the few mice surviving to adulthood show altered heart shapes but no valve or septum defects