Phenotypes Associated with This Genotype

Genotype
MGI:3620943

• Allelic Composition: Plod3^tm2.1Rmyl/Plod3^tm2.1Rmyl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung morphology ( J:106510 )

• the basement membrane and collagen fibril morphology of cells in the newborn lung is abnormal

• however, homozygotes are viable and fertile with normal kidney, heart, liver, muscle, spleen, and testis morphology

integument

abnormal cutaneous collagen fibril morphology ( J:106510 )

• collagen fibrils are more disorganized and loosely packed in bundles compared to wild-type mice

• collagen fibrils are also covered with a diffuse material not seen in wild-type mice

abnormal epidermal layer morphology ( J:106510 )

• thickness of the lamina densa is decreased in the epidermal basement membrane

cellular

impaired basement membrane formation ( J:106510 )

• thickness of the lamina densa is decreased in the epidermal basement membrane more obviously in newborns than in adults

• the basement membrane of cells in the newborn lung is also abnormal