Analysis Tools
mortality/aging
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• numbers of blastocysts are normal at E3.5, but few embryos can be detected at E6.5 or 7.5
• no embryos detected at E8.5
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embryo
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• implanted embryos are poorly organized, extensively necrotic and show no evidence of appropriate tissue differentiation
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• in cultured mutant blastocysts, after 3 days, catastrophic cell loss is seen with only a thin epitheloid layer remaining
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