Phenotypes Associated with This Genotype

Genotype
MGI:3621823

• Allelic Composition: Naip1^tm1Aem/Naip1^tm1Aem
• Genetic Background: 129X1/SvJ-Naip1^tm1Aem

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:60925 )

• following a single injection of kainic acid and induced limbic seizures

• marked difference in the level of neuronal death indicated by DNA fragmentation

• with a 2.5-fold increase in the number of cells undergoing apoptosis in pyramidal neurons of the CA3 subfield in the hippocampus

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:60925 )

• following a single injection of kainic acid and induced limbic seizures

• marked difference in the level of neuronal death indicated by DNA fragmentation

• with a 2.5-fold increase in the number of cells undergoing apoptosis in pyramidal neurons of the CA3 subfield in the hippocampus

cellular

increased susceptibility to neuronal excitotoxicity ( J:60925 )

• following a single injection of kainic acid and induced limbic seizures

• marked difference in the level of neuronal death indicated by DNA fragmentation

• with a 2.5-fold increase in the number of cells undergoing apoptosis in pyramidal neurons of the CA3 subfield in the hippocampus