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Phenotypes Associated with This Genotype
Genotype
MGI:3621825
Allelic
Composition
Cst3tm1Karl/Cst3tm1Karl
Genetic
Background
involves: 129S/SvEv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cst3tm1Karl mutation (0 available); any Cst3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in knockouts there is less neuronal damage in the cortex and striatum than in wild-type
• in knockout mice the infarct volume after 40 minutes of MCA occlusion is significantly larger than in wild-type
• global ischemia of 12 minutes caused significantly less neuronal damage in the CA3 region and dentate gyrus of knockout mice than in wild-type

homeostasis/metabolism
• in knockouts there is less neuronal damage in the cortex and striatum than in wild-type
• in knockout mice the infarct volume after 40 minutes of MCA occlusion is significantly larger than in wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory