Phenotypes Associated with This Genotype

Genotype
MGI:3621900

• Allelic Composition: Cst3^tm1Karl/Cst3^tm1Karl
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:62407 )

• after intravenous injection of melanoma cells, Cst3 knockout mice have 7 times fewer metastatic lung colonies than wild-type mice two weeks post injection

• null mice analyzed at times from 15 mnutes to 96 hours post-injection showed fewer melanoma cells as short a time as 1 minutes after injection compared to wild-type; at all time points, nulls showed fewer metatatic colonies/cells than wild-type mice; two weeks after injection, null mice had fewer melanoma colonies spread throughout their lungs than wild-type62407