Phenotypes Associated with This Genotype

Genotype
MGI:3621930

• Allelic Composition: Tap1^tm1Arp/Tap1^tm1Arp
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased double-negative T cell number ( J:3524 )

• exhibit a 30-40 fold reduction in CD4-CD8- T cells in spleen, blood and lymph nodes, but not thymus

absent CD8-positive, alpha-beta T cells ( J:3524 )

abnormal lymphocyte physiology ( J:122479 )

• class I heavy chains in spleen lymphoblasts are defective in acquisition of EndoH resistance suggesting a defect in class I maturation

abnormal antigen presentation ( J:122479 )

• when ovalbumin is introduced by osmotic shock, mutant cells show impairment in presentation of OVA-derived epitopes

abnormal dendritic cell antigen presentation ( J:112436 )

• mutant bone marrow-derived dendritic cells (BM-DC) treated with ovalbumin-immune complexes (OVA-IC) do not present the MHC class I-restricted epitope after OVA-IC internalization

decreased level of surface class I molecules ( J:3524 )

• splenocytes exhibit little or no H2-Kb or -Db surface expression, however, at lower temperatures (26C) surface expression is increased

defective intracellular transport of class I molecules ( J:3524 )

• class I Kb and Db molecules have little heavy chain sialylation indicating an impaired delivery to trans Golgi

hematopoietic system

decreased double-negative T cell number ( J:3524 )

• exhibit a 30-40 fold reduction in CD4-CD8- T cells in spleen, blood and lymph nodes, but not thymus

absent CD8-positive, alpha-beta T cells ( J:3524 )

abnormal lymphocyte physiology ( J:122479 )

• class I heavy chains in spleen lymphoblasts are defective in acquisition of EndoH resistance suggesting a defect in class I maturation