Phenotypes Associated with This Genotype

Genotype
MGI:3622422

• Allelic Composition: Postn^tm1Kudo/Postn^tm1Kudo
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal periodontal ligament morphology ( J:106783 )

• at 6 weeks of age, the shear zone (area between the tooth- and alveolus-related regions of the periodontal ligament) is obscure and by 12 weeks the shear zone is undetectable and the periodontal ligament is wider

abnormal tooth eruption ( J:106783 )

• incisor eruption is disrupted

abnormal tooth hard tissue morphology ( J:106783 )

abnormal dentin morphology ( J:106783 )

• at 6 weeks of age the dentin layer is thicker and gently waved

• by 12 weeks of age the dentin layer is compressed and undulated

abnormal enamel morphology ( J:106783 )

• incisors are a chalky, white color indicating that the enamel layers are disorganized

• at 6 weeks of age the enamel layer is thicker and gently waved

• by 12 weeks of age the enamel layer is compressed and undulated

abnormal ameloblast morphology ( J:106783 )

• at 6 weeks of age the ameloblastic layers show focal disorganization

• at 12 weeks of age the ameloblast layer is loosened, contains some non-polarized cells, gaps are seen between the polarized cells, and the morphology and alignment of cells is severely disrupted

skeleton

abnormal periodontal ligament morphology ( J:106783 )

• at 6 weeks of age, the shear zone (area between the tooth- and alveolus-related regions of the periodontal ligament) is obscure and by 12 weeks the shear zone is undetectable and the periodontal ligament is wider

abnormal tooth eruption ( J:106783 )

• incisor eruption is disrupted

abnormal tooth hard tissue morphology ( J:106783 )

abnormal dentin morphology ( J:106783 )

• at 6 weeks of age the dentin layer is thicker and gently waved

• by 12 weeks of age the dentin layer is compressed and undulated

abnormal enamel morphology ( J:106783 )

• incisors are a chalky, white color indicating that the enamel layers are disorganized

• at 6 weeks of age the enamel layer is thicker and gently waved

• by 12 weeks of age the enamel layer is compressed and undulated

abnormal ameloblast morphology ( J:106783 )

• at 6 weeks of age the ameloblastic layers show focal disorganization

• at 12 weeks of age the ameloblast layer is loosened, contains some non-polarized cells, gaps are seen between the polarized cells, and the morphology and alignment of cells is severely disrupted

growth/size/body

abnormal periodontal ligament morphology ( J:106783 )

• at 6 weeks of age, the shear zone (area between the tooth- and alveolus-related regions of the periodontal ligament) is obscure and by 12 weeks the shear zone is undetectable and the periodontal ligament is wider

abnormal tooth eruption ( J:106783 )

• incisor eruption is disrupted

abnormal tooth hard tissue morphology ( J:106783 )

abnormal dentin morphology ( J:106783 )

• at 6 weeks of age the dentin layer is thicker and gently waved

• by 12 weeks of age the dentin layer is compressed and undulated

abnormal enamel morphology ( J:106783 )

• incisors are a chalky, white color indicating that the enamel layers are disorganized

• at 6 weeks of age the enamel layer is thicker and gently waved

• by 12 weeks of age the enamel layer is compressed and undulated

abnormal ameloblast morphology ( J:106783 )

• at 6 weeks of age the ameloblastic layers show focal disorganization

• at 12 weeks of age the ameloblast layer is loosened, contains some non-polarized cells, gaps are seen between the polarized cells, and the morphology and alignment of cells is severely disrupted