Phenotypes Associated with This Genotype

Genotype
MGI:3622538

• Allelic Composition: Pecam1^tm1Mak/Pecam1^tm1Mak
• Genetic Background: D1.129P2-Pecam1^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte physiology ( J:106275 )

• larger numbers of cells from the spleen and lymph nodes of arthritic null animals migrate into the joints of arthritic mice than cells from wild-type mice

increased interferon-gamma secretion ( J:106275 )

• lymph node cells taken on day 14 from immunized mice produce significantly larger amounts of IFNG in response to stimulation by denatured CII or concanavalin A; cells obtained from mice on day 28 also produce greater amounts of IFNG in response to CII, but not concanavalin A

joint inflammation ( J:106275 )

• 6 weeks after initial CII immunization, joints of nulls showed more severe inflammation than wild-type

increased susceptibility to induced arthritis ( J:106275 )

• mice have an earlier arthritis onset after CII immunization and a higher incidence (55.3% by day 33 versus 25.7% by day42 in wild-type) than wild-type

skeleton

joint inflammation ( J:106275 )

• 6 weeks after initial CII immunization, joints of nulls showed more severe inflammation than wild-type

increased susceptibility to induced arthritis ( J:106275 )

• mice have an earlier arthritis onset after CII immunization and a higher incidence (55.3% by day 33 versus 25.7% by day42 in wild-type) than wild-type

hematopoietic system

abnormal leukocyte physiology ( J:106275 )

• larger numbers of cells from the spleen and lymph nodes of arthritic null animals migrate into the joints of arthritic mice than cells from wild-type mice