Analysis Tools
cardiovascular system
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• in knockouts, LPS treatment induces glomerular and peri-tubular capillary vascular congestion as well as occasional peritubular endothelial cell karyorexis and karyolysis, compared to induction of mild congestion in wild-type
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• after LPS treatment
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• after LPS treatment, livers from knockouts show vascular congestion
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• after LPS treatment, lungs from knockouts show vascular congestion
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• after LPS treatment, spleens from knockouts show vascular congestion of the red pulp
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• in response to LPS stimulation, one day later, a pronounced increased in organ/tissue specific permeability is observed in nulls compared to wild-type, particularly in the lung, liver, and kidney
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hematopoietic system
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• after LPS treatment, spleens from knockouts show vascular congestion of the red pulp
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homeostasis/metabolism
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• one day after LPS administration, lungs from knockouts show edema compared to treated wild-type lungs
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immune system
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• after LPS treatment, spleens from knockouts show vascular congestion of the red pulp
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• after LPS treatment over a 24-hour period, cytokine levels in the serum of null mice are elevated
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• sinusoidal and portal inflammation is observed in knockouts following LPS treatment
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liver/biliary system
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• after LPS treatment, livers from knockouts show vascular congestion
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• sinusoidal and portal inflammation is observed in knockouts following LPS treatment
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renal/urinary system
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• in knockouts, LPS treatment induces glomerular and peri-tubular capillary vascular congestion as well as occasional peritubular endothelial cell karyorexis and karyolysis, compared to induction of mild congestion in wild-type
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• after LPS treatment
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respiratory system
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• after LPS treatment, lungs from knockouts show vascular congestion
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• one day after LPS administration, lungs from knockouts show edema compared to treated wild-type lungs
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