Phenotypes Associated with This Genotype

Genotype
MGI:3622669

• Allelic Composition: Rxra^tm4Ipc/Rxra^tm4Ipc; Rxrb^tm1Pcn/Rxrb^tm1Pcn; Tg(KRT14-cre/ERT2)1Ipc/0
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop a chronic skin inflammation

immune system

enlarged spleen ( J:102470 )

• after weeks 2-8, mutants develop progressive splenomegaly

ear inflammation ( J:102470 )

• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear

increased leukocyte cell number ( J:102470 )

• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control

lymph node hyperplasia ( J:102470 )

• mutants display hyperplasia of regional lymph nodes

enlarged cervical lymph nodes ( J:102470 )

• at weeks 2 and 24, cervical lymph nodes are enlarged 2- and 10-fold respectively

dermatitis ( J:102470 )

• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions

hematopoietic system

enlarged spleen ( J:102470 )

• after weeks 2-8, mutants develop progressive splenomegaly

increased leukocyte cell number ( J:102470 )

• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control

liver/biliary system

enlarged liver ( J:102470 )

• at week 20, 50% of mutants have livers that are enlarged up to 2-fold

hearing/vestibular/ear

ear inflammation ( J:102470 )

• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear

integument

dermal cyst ( J:102470 )

dermatitis ( J:102470 )

• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions

alopecia ( J:102470 )

• mutants display progressive alopecia that is obvious by 6 weeks after Tamoxifen administration at 6 weeks of age

hair follicle degeneration ( J:102470 )

mixed cellular infiltration to dermis ( J:102470 )

• infiltrated cells and dilated blood vessels are present in the dermis; by week 24, there is heavy dermal infiltrate in mutant ears

epidermal hyperplasia ( J:102470 )

• at week 2, ear and dorsal skin biopsies show epidermal hyperplasia; at week 12. ears exhibit high epidermal hyperplasia

dry skin ( J:102470 )

• at week 6-8, mice exhibit dry skin on the trunk

scaly skin ( J:102470 )

• at week 6-8, mice exhibit scaly skin on the trunk

skin lesions ( J:102470 )

• at week 6-8, small lesions are macroscopically visible on the trunk

growth/size/body

dermal cyst ( J:102470 )

enlarged liver ( J:102470 )

• at week 20, 50% of mutants have livers that are enlarged up to 2-fold

enlarged spleen ( J:102470 )

• after weeks 2-8, mutants develop progressive splenomegaly