Analysis Tools
immune system
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• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type
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integument
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• mice develop early hair loss observed around the eyes and the dorsal skin at weeks 3 to 5
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• phenotype of adult mutant epidermis is identical to that observed in Rargtm1Ipc newborns
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• at week 5, mice show a dense dermal hyperplasia
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• mutants show a weaker infiltration of the dermis
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• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis
• with treatment with the Ppard agonist L165041, epidermis of adult mice is similar to control mice with lipids forming a continuous ribbon on top of the cornified layer
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• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae
• disorganized lamellae form aggregates at the apical pole of granular keratinocytes
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• at week 5, mice show a dense dermal hyperplasia and hyperplasic epidermis
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hematopoietic system
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• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type
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