Analysis Tools
hematopoietic system
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• stimulation of cultured thymocytes with anti-CD3 or combination of anti-CD3 and anti-CD28 does not result in increased cell death of double positive T cells from mutant mice like treatment induces in thymocytes from wild-type mice
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• there is a significant reduction in CD4+ and mature CD8+ thymocyte numbers in adult mutant mice but absolute cellularity doesn't differ between mutants and wild-type mice
• thymic cellularity in 5 week-old mice is reduced by around 50%; absolute cellularity of double positive, CD4+ and CD8+ cells is reduced significantly
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• there is a dramatic reduction in percentage of CD4+ thymocytes to less than 1% of the thymic cell population compared to that of wild-type littermates
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• relative percentage of CD8+ thymocytes is reduced by 40-60% of that in wild-type littermates
• most of the cells in the CD8+ compartment in mutants are immature compared to cells in the wild-type
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• mutant mice have about 2-fold more gamma delta T cells compared to 5 week-old control littermates
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immune system
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• stimulation of cultured thymocytes with anti-CD3 or combination of anti-CD3 and anti-CD28 does not result in increased cell death of double positive T cells from mutant mice like treatment induces in thymocytes from wild-type mice
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• there is a significant reduction in CD4+ and mature CD8+ thymocyte numbers in adult mutant mice but absolute cellularity doesn't differ between mutants and wild-type mice
• thymic cellularity in 5 week-old mice is reduced by around 50%; absolute cellularity of double positive, CD4+ and CD8+ cells is reduced significantly
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• there is a dramatic reduction in percentage of CD4+ thymocytes to less than 1% of the thymic cell population compared to that of wild-type littermates
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• relative percentage of CD8+ thymocytes is reduced by 40-60% of that in wild-type littermates
• most of the cells in the CD8+ compartment in mutants are immature compared to cells in the wild-type
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• mutant mice have about 2-fold more gamma delta T cells compared to 5 week-old control littermates
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cellular
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• stimulation of cultured thymocytes with anti-CD3 or combination of anti-CD3 and anti-CD28 does not result in increased cell death of double positive T cells from mutant mice like treatment induces in thymocytes from wild-type mice
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endocrine/exocrine glands
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• there is a significant reduction in CD4+ and mature CD8+ thymocyte numbers in adult mutant mice but absolute cellularity doesn't differ between mutants and wild-type mice
• thymic cellularity in 5 week-old mice is reduced by around 50%; absolute cellularity of double positive, CD4+ and CD8+ cells is reduced significantly
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