Phenotypes Associated with This Genotype

Genotype
MGI:3625114

• Allelic Composition: Tlr2^tm1Aki/Tlr2^tm1Aki; Tlr4^tm1Aki/Tlr4^tm1Aki
• Genetic Background: B6.129P2-Tlr2^tm1Aki Tlr4^tm1Aki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased apoptosis ( J:102879 )

• 5 days after lung injury, mutants show significantly increased numbers of apoptotic lung epithelial and inflammatory cells

homeostasis/metabolism

hyperoxia ( J:102879 )

• mutant mice are more sensitive to hyperoxia; survival time of mutants after hyperoxia exposure is reduced by almost 50% compared to wild-type

increased physiological sensitivity to xenobiotic ( J:102879 )

• double knockout mice are more susceptible to bleomycin-induced lung injury

immune system

abnormal chemokine secretion ( J:102879 )

• hyaluronan fragment-induced expression of chemokines by peritoneal macrophages is completely abolished in double knockout mice

• 5 days after lung injury, mutant mice produce significantly lower amounts of chemotactic factor KC in the alveolar space

respiratory system

abnormal lung interstitium morphology ( J:102879 )

• lung tissue from mutant mice shows evidence of enhanced injury with thickened interstitium and increased inflammatory cell accumulation within the interstitium