Phenotypes Associated with This Genotype

Genotype
MGI:3628773

hm1

• Allelic Composition: H2^b/H2^b
• Genetic Background: NOD.B10SnJ-H2^b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:14178 )

• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

endocrine/exocrine glands

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

immune system

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation