Phenotypes for Prkaca Prkacb MGI:3628809 MGI Mouse

postnatal lethality ( J:76765 )

• if mutant pups are kept with their parents, they are rejected and left out of the litter and die, probably from starvation

increased neural tube apoptosis ( J:76765 )

• increase in apoptotic cells in the dorsal and lateral regions of the neural tube

abnormal neural tube morphology ( J:76765 )

• 100% show spinal neural tube defects

• E9.5-10.5 embryos exhibit a closed neural tube with an expanded alar plate and enlarged lumen in the thoracic and lumbar regions and an expanded neuroepithelium

• E10.5 or older embryos show a drastic increase in the expansion of the neural canal (enlarged lumen) and a neuroepithelium with a higher cell density

abnormal embryonic neuroepithelium morphology ( J:76765 )

• E9.5-E10.5 embryos exhibit an expanded neuroepithelium with a higher cell density

spina bifida ( J:76765 )

• at the thoracic and lumbar regions

abnormal neuron specification ( J:76765 )

• altered neuronal identity in the neural tube posterior to the forelimb buds leading to a ventralized neural tube (appearance of ventral neuronal progenitors in the dorsal neural tube and loss of dorsal cell types)

abnormal dorsal root ganglion morphology ( J:76765 )

• dorsal root ganglia form in E10.5 embryos but regress at E12.5

• significant increase in cell death in the dorsal root ganglia adjacent to the affected neural tube

disorganized dorsal root ganglion ( J:76765 )

• dorsal root ganglia are formed in E10.5 embryos but are disorganized

abnormal vertebral column morphology ( J:76765 )

• spinal column defects are located in the thoracic and lumbar regions

abnormal spine curvature ( J:76765 )

• ventral curvature of the spine at the defective region

abnormal vertebral arch morphology ( J:76765 )

• vertebral arches fail to fuse at the dorsal midline between forelimbs and hindlimbs