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Phenotypes Associated with This Genotype
Genotype
MGI:3629408
Allelic
Composition		 Rxratm1Ipc/Rxratm4Ipc
Rxrbtm1Mma/Rxrbtm1Pcn
Tg(KRT14-cre)1Ipc/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm1Ipc mutation (0 available); any Rxra mutation (30 available)
Rxratm4Ipc mutation (0 available); any Rxra mutation (30 available)
Rxrbtm1Mma mutation (0 available); any Rxrb mutation (27 available)
Rxrbtm1Pcn mutation (0 available); any Rxrb mutation (27 available)
Tg(KRT14-cre)1Ipc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal skin morphology ( J:109090 )
• phenotype of newborn mutant epidermis is identical to that observed in Rargtm1Ipc newborns
abnormal epidermis stratum corneum morphology ( J:109090 )
• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis
abnormal keratinocyte morphology ( J:109090 )
• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae
• disorganized lamellae form aggregates at the apical pole of granular keratinocytes
abnormal skin condition ( J:109090 )
• skin of newborns appears dull

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory