Phenotypes Associated with This Genotype

Genotype
MGI:3629731

• Allelic Composition: Plcg1^tm1Ine/Plcg1^tm1Ine
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:73254 )

• homozygotes die at E8.5-E9.5

embryo

abnormal embryonic hematopoiesis ( J:73254 )

• macroscopically, E9.5 homozygotes exhibit extremely reduced hematopoiesis relative to wild-type embryos

• in vitro, mutant ES cells exhibit significantly reduced differentiation into hematopoietic cells relative to wild-type ES cells

hematopoietic system

abnormal embryonic hematopoiesis ( J:73254 )

• macroscopically, E9.5 homozygotes exhibit extremely reduced hematopoiesis relative to wild-type embryos

• in vitro, mutant ES cells exhibit significantly reduced differentiation into hematopoietic cells relative to wild-type ES cells