Phenotypes Associated with This Genotype

Genotype
MGI:3629732

• Allelic Composition: Plcg1^tm1Gcrp/Plcg1^tm1Gcrp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:39281 )

• homozygotes die at ~E9.0-E9.5; embryonic lethality is consistently observed in different genetic backgrounds, including inbred 129X1/SvJ or hybrid backgrounds 129X1/SvJ C57BL/6, 129X1/SvJ Black Swiss, and 129X1/SvJ CD-1

embryo

embryonic growth arrest ( J:39281 )

• homozygotes fail to grow and develop beyond E8.5-E9.0

embryonic growth retardation ( J:39281 )

• at E8.5, ~20% of homozygotes exhibit retarded growth and development; however, placental growth and maternal-fetal connections appear normal

• by E9.5, all homozygotes are significantly retarded in size relative to wild-type embryos

growth/size/body

embryonic growth retardation ( J:39281 )

• at E8.5, ~20% of homozygotes exhibit retarded growth and development; however, placental growth and maternal-fetal connections appear normal

• by E9.5, all homozygotes are significantly retarded in size relative to wild-type embryos