Phenotypes Associated with This Genotype

Genotype
MGI:3629778

• Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge
• Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:75054 )

♀ • Background Sensitivity: 10.5% die before weaning on a mixed 129S1/Sv and C57BL/6J background, while on a 129S background, only recover about 20% of the expected number

embryo

increased placenta weight ( J:75054 )

♀ • placentas are heavier than wild-type at E18.5

pigmentation

white spotting ( J:75054 )

♀ • 80% lack pigmentation in the feet and distal third of their tails

belly spot ( J:75054 )

♀ • about 10% exhibit white belly spotting that is confined to the ventral side around the umbilicus and has sharp borders

respiratory system

respiratory system phenotype ( J:75054 )

♀N • no evidence of abnormal lung development or respiratory infections

integument

white spotting ( J:75054 )

♀ • 80% lack pigmentation in the feet and distal third of their tails

belly spot ( J:75054 )

♀ • about 10% exhibit white belly spotting that is confined to the ventral side around the umbilicus and has sharp borders