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Phenotypes Associated with This Genotype
Genotype
MGI:3639286
Allelic
Composition		 Vamp2tm1Sud/Vamp2tm1Sud
Vamp3tm1Jpes/Vamp3tm1Jpes
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vamp2tm1Sud mutation (1 available); any Vamp2 mutation (20 available)
Vamp3tm1Jpes mutation (1 available); any Vamp3 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased miniature excitatory postsynaptic current frequency ( J:109985 )
• in hippocampal neurons from double knockout mice, frequency of miniEPSCs is ~8-fold lower than wild-type, but not different from Vamp2-single knockouts
abnormal neurotransmitter secretion ( J:109985 )
• double knockouts do not show a decrease in neurotransmitter release beyond that seen in Vamp2 single knockouts

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory