Phenotypes Associated with This Genotype

Genotype
MGI:3639861

• Allelic Composition: Dfb/Dfb⁺
• Genetic Background: BALB/cByJ-Dfb/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Absent corpus callosum in Dfb/Dfb⁺ mice

behavior/neurological

head tossing ( J:110189 )

bidirectional circling ( J:110189 )

nervous system

absent corpus callosum ( J:110189 )

• Background Sensitivity: complete penetrance of acallosal phenotype on BALB background but incomplete penetrance on a mixed BALB and C57BL/6J background

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:110189 )

• thresholds greater than 50 dB above normal

deafness ( J:110189 )

• Background Sensitivity: deafness is more severe on BALB background than on a mixed BALB and C57BL/6J background

reproductive system

small testis ( J:110189 )

♂

female infertility ( J:110189 )

♀

endocrine/exocrine glands

small testis ( J:110189 )

♂

growth/size/body

decreased body size ( J:110189 )

• heterozygotes of both genders are slightly smaller and have less fat than wildtype controls

adipose tissue

decreased percent body fat/body weight ( J:110189 )