Phenotypes Associated with This Genotype

Genotype
MGI:3652717

• Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd; Xrcc4^tm2.1Fwa/Xrcc4^tm2Fwa; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:109585 )

• mice become moribund between 12 and 14 weeks of age with 20/23 mice dead by 25 weeks

nervous system

increased medulloblastoma incidence ( J:109585 )

• mice develop medulloblastomas

abnormal cerebellar granule layer morphology ( J:109585 )

• mice at 4 and 8.5 weeks of age show multifocal tumor masses expanding from the granular layer

abnormal cerebellum vermis morphology ( J:109585 )

• at 12-14 weeks mice have aggressive medulloblastomas in the vermis or hemisphere

craniofacial

enlarged cranium ( J:109585 )

• at 12-14 weeks skulls of mice show rapid morphological enlargement

skeleton

enlarged cranium ( J:109585 )

• at 12-14 weeks skulls of mice show rapid morphological enlargement

neoplasm

increased medulloblastoma incidence ( J:109585 )

• mice develop medulloblastomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:109585