Phenotypes Associated with This Genotype

Genotype
MGI:3652766

• Allelic Composition: Fli1^tm1Ber/Fli1^tm1Ber
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:33052 )

• mice develop splenomegaly a characteristic of Friend leukemia

hematopoietic system

enlarged spleen ( J:33052 )

• mice develop splenomegaly a characteristic of Friend leukemia

anemia ( J:33052 )

• mice develop severe anemia leading to lethality characteristic of Friend leukemia

decreased hematocrit ( J:33052 )

• infected null mice show decreased hematocrits around day 55 while in wild-type, hematocrits start to drop around day 40

neoplasm

increased leukemia incidence ( J:33052 )

• null mice for Fli1 from matings of heterozygous animals infected with F-MuLV at birth develop but the disease has a consistently longer latency period than littermate controls

growth/size/body

enlarged spleen ( J:33052 )

• mice develop splenomegaly a characteristic of Friend leukemia