Phenotypes for Apoe Timp1 MGI:3652791 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Timp1^tm1Pds/Y
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel physiology ( J:103082 )

• males fed an atherogenic, high-fat diet for 10 or 22 weeks develop a higher number of ruptures in the aortic media, in which all elastic laminae are digested and infiltrated with macrophages and form pseudo-microaneurysms, than single homozygous Apoe^tm1Unc mutant males

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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