Analysis Tools
immune system
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• a defect in B cell maturation similar to that in Tg(Igh-6-Cd80)1Gjf mice is observed
• 3 week old transgenics have fewer B cells than wild-type mice; percentage of B cells in the spleens of young wild-type is 54% vs 25% in transgenics
• adult mice have comparable numbers of B cells in the spleens to wild-type
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• transgene expressing T cells can be activated by anti-CD3 alone, whereas wild-type T cells require presence of costimulatory signals for activation
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• T cells stimulated with wild-type B cells show poor activation in contrast to cells stimulated with B cells expressing the transgene
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• in response to TNP-KLH, T cell responses are normal but B cell antibody responses are reduced
• when mice are treated with anti-Cd80, capacity to produce antibodies in response to hapten-protein conjugates is restored
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• all Ig isotypes are reduced in transgenic mice in response to TNP-KLH; the same defect is seen with another hapten conjugate TNP-ovalbumin
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hematopoietic system
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• a defect in B cell maturation similar to that in Tg(Igh-6-Cd80)1Gjf mice is observed
• 3 week old transgenics have fewer B cells than wild-type mice; percentage of B cells in the spleens of young wild-type is 54% vs 25% in transgenics
• adult mice have comparable numbers of B cells in the spleens to wild-type
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• all Ig isotypes are reduced in transgenic mice in response to TNP-KLH; the same defect is seen with another hapten conjugate TNP-ovalbumin
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• transgene expressing T cells can be activated by anti-CD3 alone, whereas wild-type T cells require presence of costimulatory signals for activation
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• T cells stimulated with wild-type B cells show poor activation in contrast to cells stimulated with B cells expressing the transgene
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