Analysis Tools
mortality/aging
 |
• male hemizygotes survive well if no injury occurs but occasionally exhibit sudden death during growth, mostly as a result of internal hemorrhage after normal fighting with littermates
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homeostasis/metabolism
|
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• male hemizygotes display a severe hemophilia B phenotype with reduced plasma clotting activity although an 8% residual activity is observed
• when their tails are cut, male hemizygotes bleed and die if the wound is not cauterized
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cardiovascular system
|
N |
• at 13 weeks of age, prohemorrhagic male hemizygotes display normal hearts with no evidence of hemosiderin deposition
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hemorrhage
(
J:44497
)
|
|
• male hemizygotes are grossly normal but display spontaneous bleeding, as shown by hemorrhagic swelling of the top of the feet or of the footpads or the presence of pale footpads
• at autopsy, male hemizygotes show massive hemorrhages, mostly subcutaneous or in the dorsal surface musculature
• intra-cranial hemorrhages, hemorrhages in the axilliary and inguinal areas, hemorrhages around the salivary glands, and hemorrhages in the pericardium are also observed
|
|
|
• male hemizygotes display fatal internal hemorrhage after normal fighting with littermates
|
hematopoietic system
|
|
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
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immune system
|
|
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
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growth/size/body
|
|
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hemophilia B | DOID:12259 |
OMIM:306900 |
J:44497 | |
