Phenotypes Associated with This Genotype

Genotype
MGI:3662905

• Allelic Composition: Ret^tm1.1Kln/Ret^tm1.1Kln
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:110955 )

• at E11.5 in nulls, the developing ventral branch of axons coming from the sciatic plexus appear thicker while the dorsal branch is reduced; most embryos displayed defects categorized as intermediate reductions (Category II: intermediate reductions)

• at E12.5 the branchpoint of peroneal nerve (PN) seen in wild-type is absent or has become the most distal extension of the peroneal nerve which is also reduced in diameter; in most severe cases, nerve is almost completely absent

• mutants have peroneal nerves of reduced length (~40% of control) at E11.5