Phenotypes Associated with This Genotype

Genotype
MGI:3663483

• Allelic Composition: Lepr^tm1.1Chua/Lepr^tm1.1Chua; Tg(Nr5a1-cre)2Lowl/0
• Genetic Background: involves: 129 * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:105327 )

• increase in fat mass but no difference in lean mass

abnormal fat pad morphology ( J:105327 )

• size of fat pads (perigonadal and perirenal) is increased

abnormal gonadal fat pad morphology ( J:105327 )

• size of perigonadal fat pads is increased

abnormal renal fat pad morphology ( J:105327 )

• size of perirenal fat pads is increased

growth/size/body

increased body weight ( J:105327 )

• 15% increase in body weight at 20 weeks of age compared to controls; degree of obesity is about 20% of that seen in homozygous Lepr^tm1.2Chua mice

increased susceptibility to diet-induced obesity ( J:105327 )

• rapidly gain weight when fed a high-fat diet compared to controls; weight gain is reflected by increases in fat mass

• when switch from a regular chow to a high-fat diet at 8 weeks of age, mutants gain substantially greater amounts of weight than controls

homeostasis/metabolism

increased circulating leptin level ( J:105327 )

abnormal energy expenditure ( J:105327 )

• show marked impairment in ability to activate diet-induced thermogenesis in response to a high-fat diet

increased susceptibility to diet-induced obesity ( J:105327 )

• rapidly gain weight when fed a high-fat diet compared to controls; weight gain is reflected by increases in fat mass

• when switch from a regular chow to a high-fat diet at 8 weeks of age, mutants gain substantially greater amounts of weight than controls

nervous system

abnormal nervous system electrophysiology ( J:105327 )

• leptin has no effect on either membrane potential or firing rate of neurons unlike in controls which show depolarization and increased firing rate in response to leptin

behavior/neurological

increased food intake ( J:105327 )

• fail to suppress food intake over time when fed a high fat diet