Phenotypes Associated with This Genotype

Genotype
MGI:3663893

• Allelic Composition: Metap2^tm1.1Ccr/Metap2^tm1.1Ccr; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:111701 )

• survive past early gestation period but die by E10.5

growth/size/body

decreased embryo size ( J:111701 )

• appear smaller at E9.5

embryo

embryonic growth arrest ( J:111701 )

• develop to midsomite stage (E8.5) but become arrested and necrotic at E9.5

decreased embryo size ( J:111701 )

• appear smaller at E9.5

disorganized embryonic tissue ( J:111701 )

• embryos appear disorganized at E9.5

embryo tissue necrosis ( J:111701 )

• embryos become necrotic at E9.5

cardiovascular system

abnormal blood vessel morphology ( J:111701 )

decreased vascular endothelial cell number ( J:111701 )

• embryos contain fewer PECAM-positive endothelial cells

abnormal intersomitic vessel morphology ( J:111701 )

• intersomitic vessels are either poorly developed or fail to be distinguished

abnormal vascular development ( J:111701 )

• blood vessels, such as the dorsal aorta, intersomitic vessels, and small capillary plexus are either poorly developed or fail to be distinguished, indicating arrest of vascular development

abnormal dorsal aorta morphology ( J:111701 )

• dorsal aorta is either poorly developed or fails to be distinguished