Analysis Tools
immune system
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• in older mice numbers of activated/memory T cells increases; however, these cells contain only unrecombined alleles
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• markedly reduced numbers of peripheral T cells
• at 4 - 6 months of age almost no naive T cells are found in the spleen and lymph nodes
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• severe decrease in the number of CD24low mature cells while the number of CD24high immature cells is similar to controls
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• severe decrease in the number of CD24low mature cells while the number of CD24high immature cells is similar to controls
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• no detectable regulatory T cells in the thymus or spleen at 6 weeks of age
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• decreased numbers of single positive T cells, especially CD8+ cells, while the numbers of double negative and double positive T cells is similar to controls
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• seen at 4 - 6 months of age
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• increase in the numbers of myeloid lineage cells (macrophages, neutrophils) but almost a complete absence of naive T cells is detected at 4 - 6 months of age
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• dose-dependent induction of cell death in response to TNF stimulation unlike controls cells which are viable after TNF stimulation
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• impaired proliferation in response to anti-CD3 stimulation with or without co-stimulation by anti-CD28
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• seen at 4 - 6 months of age
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digestive/alimentary system
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• at 4 - 6 months of age, loss of goblet cells is seen in the large intestine but not in the small intestine
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• prominent ulceration is seen at 4 - 6 months of age in the large, but not the small, intestine
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• stiff colon present at 4 - 6 months of age
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• seen at 4 - 6 months of age
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• severe diarrhea beginning at 4 - 6 months of age
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growth/size/body
weight loss
(
J:112837
)
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• begins at 4 - 6 months of age
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• seen at 4 - 6 months of age
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• increase in the numbers of myeloid lineage cells (macrophages, neutrophils) but almost a complete absence of naive T cells is detected at 4 - 6 months of age
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hematopoietic system
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• in older mice numbers of activated/memory T cells increases; however, these cells contain only unrecombined alleles
|
|
• markedly reduced numbers of peripheral T cells
• at 4 - 6 months of age almost no naive T cells are found in the spleen and lymph nodes
|
|
• severe decrease in the number of CD24low mature cells while the number of CD24high immature cells is similar to controls
|
|
• severe decrease in the number of CD24low mature cells while the number of CD24high immature cells is similar to controls
|
|
• no detectable regulatory T cells in the thymus or spleen at 6 weeks of age
|
|
• decreased numbers of single positive T cells, especially CD8+ cells, while the numbers of double negative and double positive T cells is similar to controls
|
|
• seen at 4 - 6 months of age
|
|
• increase in the numbers of myeloid lineage cells (macrophages, neutrophils) but almost a complete absence of naive T cells is detected at 4 - 6 months of age
|
|
• dose-dependent induction of cell death in response to TNF stimulation unlike controls cells which are viable after TNF stimulation
|
|
• impaired proliferation in response to anti-CD3 stimulation with or without co-stimulation by anti-CD28
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cellular
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• at 4 - 6 months of age, loss of goblet cells is seen in the large intestine but not in the small intestine
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• impaired proliferation in response to anti-CD3 stimulation with or without co-stimulation by anti-CD28
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