Analysis Tools
mortality/aging
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• mutants show 76% survival rate 30 days after bleomycin treatment vs 100% in wild-type
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growth/size/body
weight loss
(
J:112941
)
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• mutants show 33.3% weight reduction 7 days after bleomycin treatment vs 26.6% decrease observed in treated wild-type
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respiratory system
|
N |
• fibrotic response to lung injury is similar in mutants and wild-type; Timp1-deficiency does not alter collagen accumulation
• neutrophil chemotactic activity is not different from wild-type, following bleomycin treatment
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• at day 7, bleomycin-treated mutants show 3-fold higher concentrations of erythrocytes in BAL vs wild-type; number of erythrocytes per unit area of lung is >4-fold higher vs wild-type at day 7
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• tissue sections show extensive neutrophil accumulation at day7 after bleomycin treatment vs wild-type
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hematopoietic system
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• percentage and concentration are 2-fold higher compared to wild-type by day 3 following treatment, and at day 7, concentration is 3.5-fold higher and percentage is 1.5 time higher compared to controls
• at day 7 after treatment, BAL neutrophil percentage and concentration are 3- and 10-fold higher in Timp1-null mice compared to Timp2-null animals; values for Timp2-null mice are similar to wild-type
• concentrations of alveolar macrophages or lymphocytes recovered from treated mutants are similar to those in treated wild-type
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immune system
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• percentage and concentration are 2-fold higher compared to wild-type by day 3 following treatment, and at day 7, concentration is 3.5-fold higher and percentage is 1.5 time higher compared to controls
• at day 7 after treatment, BAL neutrophil percentage and concentration are 3- and 10-fold higher in Timp1-null mice compared to Timp2-null animals; values for Timp2-null mice are similar to wild-type
• concentrations of alveolar macrophages or lymphocytes recovered from treated mutants are similar to those in treated wild-type
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• tissue sections show extensive neutrophil accumulation at day7 after bleomycin treatment vs wild-type
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cardiovascular system
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• at day 7, bleomycin-treated mutants show 3-fold higher concentrations of erythrocytes in BAL vs wild-type; number of erythrocytes per unit area of lung is >4-fold higher vs wild-type at day 7
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• pulmonary vaculature in bleomycin-treated mice shows greater leakage than similarly treated wild-type animals
• mice exposed to bleomycin display a large increase in albumin and IgM in bronchoalveolar lavage (BAL) compared with saline treated animals; albumin concentrations in BAL are increased >1.5-fold compared to treated wild-type mice at 2, 5, and 7 days after bleomycin treatment
• IgM concentrations also increase in the week following bleomycin, but it does not reach significance compared to wild-type
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