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Phenotypes Associated with This Genotype
Genotype
MGI:3664802
Allelic
Composition
Timp1tm1Pds/Timp1tm1Pds
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp1tm1Pds mutation (1 available); any Timp1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants show 76% survival rate 30 days after bleomycin treatment vs 100% in wild-type

growth/size/body
• mutants show 33.3% weight reduction 7 days after bleomycin treatment vs 26.6% decrease observed in treated wild-type

respiratory system
N
• fibrotic response to lung injury is similar in mutants and wild-type; Timp1-deficiency does not alter collagen accumulation
• neutrophil chemotactic activity is not different from wild-type, following bleomycin treatment
• at day 7, bleomycin-treated mutants show 3-fold higher concentrations of erythrocytes in BAL vs wild-type; number of erythrocytes per unit area of lung is >4-fold higher vs wild-type at day 7
• tissue sections show extensive neutrophil accumulation at day7 after bleomycin treatment vs wild-type

hematopoietic system
• percentage and concentration are 2-fold higher compared to wild-type by day 3 following treatment, and at day 7, concentration is 3.5-fold higher and percentage is 1.5 time higher compared to controls
• at day 7 after treatment, BAL neutrophil percentage and concentration are 3- and 10-fold higher in Timp1-null mice compared to Timp2-null animals; values for Timp2-null mice are similar to wild-type
• concentrations of alveolar macrophages or lymphocytes recovered from treated mutants are similar to those in treated wild-type

immune system
• percentage and concentration are 2-fold higher compared to wild-type by day 3 following treatment, and at day 7, concentration is 3.5-fold higher and percentage is 1.5 time higher compared to controls
• at day 7 after treatment, BAL neutrophil percentage and concentration are 3- and 10-fold higher in Timp1-null mice compared to Timp2-null animals; values for Timp2-null mice are similar to wild-type
• concentrations of alveolar macrophages or lymphocytes recovered from treated mutants are similar to those in treated wild-type
• tissue sections show extensive neutrophil accumulation at day7 after bleomycin treatment vs wild-type

cardiovascular system
• at day 7, bleomycin-treated mutants show 3-fold higher concentrations of erythrocytes in BAL vs wild-type; number of erythrocytes per unit area of lung is >4-fold higher vs wild-type at day 7
• pulmonary vaculature in bleomycin-treated mice shows greater leakage than similarly treated wild-type animals
• mice exposed to bleomycin display a large increase in albumin and IgM in bronchoalveolar lavage (BAL) compared with saline treated animals; albumin concentrations in BAL are increased >1.5-fold compared to treated wild-type mice at 2, 5, and 7 days after bleomycin treatment
• IgM concentrations also increase in the week following bleomycin, but it does not reach significance compared to wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory