Phenotypes Associated with This Genotype

Genotype
MGI:3664937

• Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho; Tnf^tm1Gkl/Tnf^tm1Gkl
• Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated heart left ventricle ( J:112033 )

• double mutants subjected to cardiac pressure overload show a greater increase in left ventricle dilation after 3 weeks than wildtype but less than seen in single Timp3 homozygous mutants

decreased heart ventricle muscle contractility ( J:112033 )

• double mutants subjected to cardiac pressure overload show a greater decline in cardiac contractility than wild-type but not as much as single Timp3 homozygous mutants

hematopoietic system

increased neutrophil cell number ( J:112033 )

• myocardium of double mutants subjected to cardiac pressure overload contains significantly higher numbers of neutrophils scattered throughout the left ventricle compared with single homozygous Timp3 mutants or wild-type

immune system

increased neutrophil cell number ( J:112033 )

• myocardium of double mutants subjected to cardiac pressure overload contains significantly higher numbers of neutrophils scattered throughout the left ventricle compared with single homozygous Timp3 mutants or wild-type

muscle

decreased heart ventricle muscle contractility ( J:112033 )

• double mutants subjected to cardiac pressure overload show a greater decline in cardiac contractility than wild-type but not as much as single Timp3 homozygous mutants