Phenotypes Associated with This Genotype

Genotype
MGI:3665126

• Allelic Composition: Atp2b2^jog/Atp2b2^jog
• Genetic Background: involves: C57BL/6 * DSO

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:111625 )

• at P12, body weights of mutants are slightly less than wild-type; from 3 weeks onward, body weights are significantly lower

behavior/neurological

limb grasping ( J:111625 )

tremors ( J:111625 )

• mild tremors of the trunk are observed

ataxia ( J:111625 )

• ataxia manifests by postnatal day 12 and worsens after that point; hindlimbs are more affected than hindlimbs

• hesitant, joggling gait is displayed

impaired limb coordination ( J:111625 )

• mice display faulty coordination of the hind legs

abnormal posture ( J:111625 )

• mice have difficulty maintaining normal posture; writhing of the trunk during walking is observed

nervous system

small cerebellum ( J:111625 )

• at P21, cerebellum weights of homozygotes are significantly lower than wild-type; ratio of cerebellar to brain weight is lower in mutants from 3 weeks to 5 months of age

cellular

abnormal cell death ( J:111625 )

• cerebellar cortex of mutants displays many dead cells from P12 to 5 months of age