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Phenotypes Associated with This Genotype
Genotype
MGI:3665550
Allelic
Composition		 Shhtm1Chg/Shh+
Tg(Shh)#Dje/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shhtm1Chg mutation (2 available); any Shh mutation (48 available)
Tg(Shh)#Dje mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellum morphology ( J:94461 )
• partial loss of Shh partially rescues Tg(Shh)#Dje phenotype; at E18.5, in some animals, cerebellum is slightly smaller than that of transgenics alone
abnormal cerebellar granule layer morphology ( J:94461 )
• IGL is not as thick or irregular as that of Shh transgenic mice and overall size is reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory