Phenotypes Associated with This Genotype

Genotype
MGI:3686594

• Allelic Composition: Gria2^tm2Rsp/Gria2⁺; Tg(Camk2a-cre)1Gsc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

seizures ( J:111689 )

• seizure episodes are observed, while none are seen in forebrain-specific knockouts

nervous system

seizures ( J:111689 )

• seizure episodes are observed, while none are seen in forebrain-specific knockouts

abnormal neuron differentiation ( J:111689 )

• 2-fold increase in mitotic and postmitotic neurogenic cells is observed in subgranular zone (SGZ)

abnormal brain interneuron morphology ( J:111689 )

• there is loss of interneurons in hippocampus

loss of hippocampal neurons ( J:111689 )

• loss of somatostatin-positive interneurons in hilus and stratum oriens of the CA1 is observed

abnormal CNS glial cell morphology ( J:111689 )

• there are an increased number of glia seen in the amydala, motor cortex and somatosensory cortex

cellular

abnormal neuron differentiation ( J:111689 )

• 2-fold increase in mitotic and postmitotic neurogenic cells is observed in subgranular zone (SGZ)