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Phenotypes Associated with This Genotype
Genotype
MGI:3687169
Allelic
Composition		 H2g7/H2g7
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (24 available); any H2 mutation (281 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:111874 )
• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected

immune system
insulitis ( J:111874 )
• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected
decreased susceptibility to autoimmune diabetes ( J:111874 )
• transgenic Rag1-sufficient mice do not develop diabetes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory