Analysis Tools
cellular
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• neurons show increased survival vs wild-type after camptothecin treatment
• neurons cultured in pyruvate supplemented media show increased survival after camptothecin treatment
• expression of anchored Pdcd8 does not provide further protection from death to neurons
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• cultured neurons show increased apoptosis reconstituted with wild-type Pdcd8 compared to control; mutant neurons expressing Pdcd8 with a nuclear exclusion sequence show cell death equivalent to control neurons expressing GFP
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• cultured neurons can maintain oxygen consumption after camptothecin treatment if anchored Pdcd8 is expressed
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nervous system
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• neurons show increased survival vs wild-type after camptothecin treatment
• neurons cultured in pyruvate supplemented media show increased survival after camptothecin treatment
• expression of anchored Pdcd8 does not provide further protection from death to neurons
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• cultured neurons show increased apoptosis reconstituted with wild-type Pdcd8 compared to control; mutant neurons expressing Pdcd8 with a nuclear exclusion sequence show cell death equivalent to control neurons expressing GFP
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• cortex is thickened compared to Pdcd8 conditional embryos
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