About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3687325
Allelic
Composition		 Hprt1tm1(CUX1)Anep/Hprt1+
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CUX1)Anep mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system morphology/development ( J:113393 )
• 33% of female mice develop a hematopoietic disorder and display enlarged spleens
spleen hyperplasia ( J:113393 )
• spleen enlargement results from myeloid hyperplasia
decreased erythrocyte cell number ( J:113393 )
• number of red blood cells is significantly decreased
decreased hematocrit ( J:113393 )
• hematocrit is significantly decreased
decreased mean corpuscular hemoglobin concentration ( J:113393 )
• hemoglobin concentration is significantly decreased
decreased B cell number ( J:113393 )
• B cells are underrepresented in spleen, bone marrow, liver and blood of transgenic mice
increased leukocyte cell number ( J:113393 )
• WBC numbers are significantly increased; in most cases, increase is due to increased neutrophil numbers
increased neutrophil cell number ( J:113393 )
• there is an excess of neutrophils in blood, spleen, bone marrow and liver of mice, as wel as lungs and kidneys in many cases
abnormal spleen white pulp morphology ( J:113393 )
• regions of white pulp are seen to be compressed
abnormal splenic cell ratio ( J:113393 )
• spleens contain large number of cells resembling polymorphonuclear leukocytes; neutrophils, granulocytes and megakaryocytes are present in increased numbers compared to wild-type
abnormal hematopoietic system physiology ( J:113393 )
• transgenic mice (33% incidence) are ~4 times more susceptible to the hematopoietic disorder than non transgenic littermates (8.6% incidence)

immune system
spleen hyperplasia ( J:113393 )
• spleen enlargement results from myeloid hyperplasia
decreased B cell number ( J:113393 )
• B cells are underrepresented in spleen, bone marrow, liver and blood of transgenic mice
increased leukocyte cell number ( J:113393 )
• WBC numbers are significantly increased; in most cases, increase is due to increased neutrophil numbers
increased neutrophil cell number ( J:113393 )
• there is an excess of neutrophils in blood, spleen, bone marrow and liver of mice, as wel as lungs and kidneys in many cases
abnormal spleen white pulp morphology ( J:113393 )
• regions of white pulp are seen to be compressed
abnormal splenic cell ratio ( J:113393 )
• spleens contain large number of cells resembling polymorphonuclear leukocytes; neutrophils, granulocytes and megakaryocytes are present in increased numbers compared to wild-type
enlarged lymph nodes ( J:113393 )
• one mouse had enlarged lymph nodes containing mostly B cells

liver/biliary system
abnormal liver morphology ( J:113393 )
• livers of sick mice have unusual color and texture; there is an overrepresentation of leukocytes in the livers

respiratory system
abnormal lung morphology ( J:113393 )
• lungs of sick mice have unusual color and texture; there is an overrepresentation of leukocytes in the livers

growth/size/body
enlarged spleen ( J:113393 )
spleen hyperplasia ( J:113393 )
• spleen enlargement results from myeloid hyperplasia

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory