Phenotypes Associated with This Genotype

Genotype
MGI:3687458

• Allelic Composition: Srsf3^tm1Pjln/Srsf3^tm1Pjln; Cd79a^tm1(cre)Reth/Cd79a⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased pro-B cell number ( J:113645 )

• strong reduction in number of B cell precursors is seen in bone marrow

decreased B cell number ( J:113645 )

• drastic reductions in B cell number are found in spleen, thymus, and bone marrow

decreased pre-B cell number ( J:113645 )

• drastic reduction in pre-B cells indicates that Sfrs3 is required for pre-B cell survival

hematopoietic system

decreased pro-B cell number ( J:113645 )

• strong reduction in number of B cell precursors is seen in bone marrow

decreased B cell number ( J:113645 )

• drastic reductions in B cell number are found in spleen, thymus, and bone marrow

decreased pre-B cell number ( J:113645 )

• drastic reduction in pre-B cells indicates that Sfrs3 is required for pre-B cell survival