Phenotypes Associated with This Genotype

Genotype
MGI:3687543

• Allelic Composition: Shh^tm1Chg/Shh^tm2Chg; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:125109 )

limbs/digits/tail

abnormal carpal bone morphology ( J:109101 )

• exhibit defective development of the carpal and tarsal bones in the central digit

abnormal digit morphology ( J:109101 )

• in the forelimb, digit 2 is replaced with a biphalangeal digit characteristic of digit 1

• in the hindlimb, digit 1 is replaced by digits with more posterior characteristics

abnormal tarsal bone morphology ( J:109101 )

• exhibit defective development of the carpal and tarsal bones in the central digit

skeleton

abnormal carpal bone morphology ( J:109101 )

• exhibit defective development of the carpal and tarsal bones in the central digit

abnormal tarsal bone morphology ( J:109101 )

• exhibit defective development of the carpal and tarsal bones in the central digit