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Phenotypes Associated with This Genotype
Genotype
MGI:3687955
Allelic
Composition		 Stat5atm1Mam/Stat5atm1Mam
Genetic
Background		 either: 129S6/SvEvTac-Stat5atm1Mam or (involves: 129S6/SvEvTac * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm1Mam mutation (3 available); any Stat5a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:64278 )
• ductal development appears normal but lobuloalveolar outgrowth is severely reduced, secretory tissue is sparse, and alveoli are petite and contain small lumina
abnormal mammary gland growth during lactation ( J:64278 )
• lubuloalveolar units are underdeveloped and do not exhibit a secretory phenotype, even after maximal stimulation of prolactin secretion induced by suckling
abnormal mammary gland growth during pregnancy ( J:64278 )
• mammary lobuloalveolar outgrowth during pregnancy is curtailed
lactation failure ( J:64278 )
• females fail to lactate after parturition because of a failure of terminal differentiation
• continued suckling does not result in milk production and release, however expression of milk protein genes and synthesis of milk proteins is maintained and the gland does not involute

reproductive system
abnormal mammary gland growth during pregnancy ( J:64278 )
• mammary lobuloalveolar outgrowth during pregnancy is curtailed

integument
abnormal branching of the mammary ductal tree ( J:64278 )
• ductal development appears normal but lobuloalveolar outgrowth is severely reduced, secretory tissue is sparse, and alveoli are petite and contain small lumina
abnormal mammary gland growth during lactation ( J:64278 )
• lubuloalveolar units are underdeveloped and do not exhibit a secretory phenotype, even after maximal stimulation of prolactin secretion induced by suckling
abnormal mammary gland growth during pregnancy ( J:64278 )
• mammary lobuloalveolar outgrowth during pregnancy is curtailed
lactation failure ( J:64278 )
• females fail to lactate after parturition because of a failure of terminal differentiation
• continued suckling does not result in milk production and release, however expression of milk protein genes and synthesis of milk proteins is maintained and the gland does not involute

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory