Phenotypes Associated with This Genotype

Genotype
MGI:3688423

• Allelic Composition: Stat5b^tm1Hwd/Stat5b^tm1Hwd
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:112035 )

• splenocytes exhibit greatly diminished proliferation in response to IL-2 and IL-15 and a combination of PMA and IL-4

abnormal lymphocyte morphology ( J:112035 )

abnormal double-negative T cell morphology ( J:112035 )

• among the double negative cells, there is a moderate decrease in the percentage of CD44+CD25- cells and an increase in the percentage of CD44-CD25+ cells

abnormal lymphocyte cell number ( J:112035 )

• the T/B cell ratio is slightly decreased

decreased thymocyte number ( J:112035 )

• thymocyte numbers are modestly diminished

decreased NK cell number ( J:112035 )

• percentage of NK (CD3-DX5+) cells is diminished (about 55% of the percentage seen in wild-type)

• exhibit a decrease in IL2-Rbeta+ NK cells

decreased CD8-positive, alpha-beta T cell number ( J:112035 )

• exhibit diminished numbers of single positive splenocytes; the number of CD4-CD8+ splenocytes is reduced, whereas, the number of CD4+CD8- cells is only slightly affected

decreased splenocyte number ( J:112035 )

• exhibit decreased numbers of splenocytes in the periphery

impaired natural killer cell mediated cytotoxicity ( J:112035 )

• NK cytolytic activity is impaired

hematopoietic system

decreased T cell proliferation ( J:112035 )

• splenocytes exhibit greatly diminished proliferation in response to IL-2 and IL-15 and a combination of PMA and IL-4

abnormal lymphocyte morphology ( J:112035 )

abnormal double-negative T cell morphology ( J:112035 )

• among the double negative cells, there is a moderate decrease in the percentage of CD44+CD25- cells and an increase in the percentage of CD44-CD25+ cells

abnormal lymphocyte cell number ( J:112035 )

• the T/B cell ratio is slightly decreased

decreased thymocyte number ( J:112035 )

• thymocyte numbers are modestly diminished

decreased NK cell number ( J:112035 )

• percentage of NK (CD3-DX5+) cells is diminished (about 55% of the percentage seen in wild-type)

• exhibit a decrease in IL2-Rbeta+ NK cells

decreased CD8-positive, alpha-beta T cell number ( J:112035 )

• exhibit diminished numbers of single positive splenocytes; the number of CD4-CD8+ splenocytes is reduced, whereas, the number of CD4+CD8- cells is only slightly affected

decreased splenocyte number ( J:112035 )

• exhibit decreased numbers of splenocytes in the periphery

impaired natural killer cell mediated cytotoxicity ( J:112035 )

• NK cytolytic activity is impaired

endocrine/exocrine glands

decreased thymocyte number ( J:112035 )

• thymocyte numbers are modestly diminished

cellular

decreased T cell proliferation ( J:112035 )

• splenocytes exhibit greatly diminished proliferation in response to IL-2 and IL-15 and a combination of PMA and IL-4