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Phenotypes Associated with This Genotype
Genotype
MGI:3689505
Allelic
Composition		 Smad2tm1Rob/Smad2tm2Rob
Smad3tm1Xfw/Smad3+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Smad2tm1Rob mutation (0 available); any Smad2 mutation (52 available)
Smad2tm2Rob mutation (1 available); any Smad2 mutation (52 available)
Smad3tm1Xfw mutation (0 available); any Smad3 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
rostral body truncation ( J:84300 )
• embryos develop severe anterior truncations at E8.5
fused somites ( J:84300 )
• somites are fused across the midline at E8.5

digestive/alimentary system
absent foregut ( J:84300 )
• anterior gut is absent

cardiovascular system
abnormal heart development ( J:84300 )
• embryos develop heart malformations at E8.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory