Phenotypes Associated with This Genotype

Genotype
MGI:3689862

• Allelic Composition: Klhl1/Atxn8os^tm1Mdk/Klhl1/Atxn8os^tm1Mdk; Tg(Pcp2-cre)3Mdk/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:112937 )

• loss of motor coordination at 24 weeks of age in a rotarod test

nervous system

thin cerebellar molecular layer ( J:112937 )

• layer normal at 6 weeks but definitely thinner at 24 weeks of age

• dendritic atrophy of Purkinje cells seen but Purkinje cells themselves display an overall normal morphology